黎鹏，深圳理工大学细胞与基因技术研究院特聘副教授。研究方向聚焦于营养与代谢分子调控T细胞抗肿瘤免疫应答的机制与功能，特别关注γδ T细胞抗肿瘤免疫的临床转化研究。主持国家自然科学基金专项项目，国家自然科学基金青年科学基金项目(C类)，广东省基础与应用基础研究基金（粤穗联合青年项目），中国博士后科学基金面上项目，同时参与国家自然科学基金及省部级项目5项。近年来以第一作者/通讯作者/参与作者在《JITC》、《Gut Microbes》、《Theranostics》、《Immunology》、《JCI》、《Science Bulletin》等国际期刊发表论文12篇，并担任JITC, Advanced Science, Clinical and Translational Medicine, Cell Communication and Signaling等期刊审稿人。

2015.09-2021.06，暨南大学，生物化学与分子生物学，博士

2011.09-2015.06，湖北恩施学院，生物工程，学士

2021.10-2025.09，暨南大学，博士后

2025.10-至今，深圳理工大学，细胞与基因技术研究院，特聘副教授

营养与肿瘤免疫治疗。

项目承担

1.国家自然科学基金委员会,专项项目,2026-01-01至2028-12-31, 58万元,在研,主持。

2.国家自然科学基金委员会,青年科学基金项目(C类), 2024-01-01至2026-12-31, 30万元,在研,主持。

3.广东省基础与应用基础研究基金省市联合基金,青年基金项目, 2022-10-01至2025-09-30, 10万元,结题,主持。

4.中国博士后科学基金会,面上项目,2022-07-01至2023-12-31, 8万元,结题,主持。

5.广东省基础与应用基础研究基金省市联合基金(粤佛),地区培育项目,2025-01-01至2027-12-31, 30万元,在研,联合申请。

代表性文章

1.Peng Li#, Xinhai Zhu#, Guangchao Cao#, Ruan Wu, Ke Li, Wenhui Yuan, Biyun Chen, Guodong Sun, Xichun Xia, Hua Zhang, Xiao Wang, Zhinan Yin*, Ligong Lu*, Yunfei Gao*. 1α,25(OH)₂D₃reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells.Journal for ImmunoTherapy of Cancer. 2022, 10(3): e003477.

2.Peng Li#^,*, Ke Li#, Wenhui Yuan#, Yuqi Xu, Ping Li, Ruan Wu, Jingru Han, Zhinan Yin*, Ligong Lu*, Yunfei Gao*. 1α,25(OH)₂D₃ameliorates insulin resistance by alleviatingγδT cell inflammation via enhancing fructose-1,6-bisphosphatase 1 expression.Theranostics. 2023, 13(15): 5290-5304.

3. Xinhai Zhu#, Ke Li#, Guichao Liu#, Ruan Wu, Yan Zhang, Siying Wang, Meng Xu*, Ligong Lu*,Peng Li*. Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell.Gut Microbes. 2023, 15(2): 2249143.(ESI高被引).

4.Yuqi Xu#, Wenhui Yuan#, Ke Li*,Peng Li*.Nutritional intervention alleviates T cell exhaustion and empowers anti-tumor immunity.Frontiers in Immunology. 2025,16:1689317.

5. Ke Li, Eying Lu, Qian Wang, Ruirong Xu, Wenhui Yuan, Ruan Wu, Ligong Lu*,Peng Li*. Serum vitamin D deficiency is associated with increased risk of γδ T cell exhaustion in HBV-infected patients.Immunology. 2024, 171(1): 31-44.

6. Dongdong Zhang#, Guichao Liu#, Jinhui Ye#, Ke Li, Guojun Zhang, Qiang Quan*, Xinhai Zhu*,Peng Li*.Low-exhaustion peripheral circulatingγδT cells serve as a biomarker for predicting the clinical benefit rate of non-small cell lung cancer (NSCLC) patients to chemotherapy or targeted therapy: a single-center retrospective study.BMC Cancer. 2025; 25 (178).

7. Guichao Liu#, Qiang Quan#, Lanhong Pan#, Haibo Duan#, Guojun Zhang, Ke Li, Xinhai Zhu*, Dongdong Zhang*,Peng Li*,Jianfu Zhao*. Retinoic acid enhances gammadelta T cell cytotoxicity in nasopharyngeal carcinoma by reversing immune exhaustion.Cell Communication and Signaling. 2025, 23(1):156.

8. Xichun Xia#, Guangchao Cao#, Guodong Sun#, Leqing Zhu, Yixia Tian, Yueqi Song, Chengbin Guo, Xiao Wang, Jingxiang Zhong, Wei Zhou,Peng Li, Hua Zhang, Jianlei Hao, Zhizhong Li, Liehua Deng*, Zhinan Yin*, Yunfei Gao*. GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.Journal of Clinical Investigation. 2020, 130(10): 5180-5196.

9. Hua Zhang#, Guodong Sun#, Xiaowei Li, Zhen Fu, Chengbin Guo, Guangchao Cao, Baocheng Wang Qian Wang, Shuxian Yang, Dehai Li, Xichun Xia,Peng Li, Jing Zhu, Wei Zhou, Liangyan Zheng, Jingxia Li, Lei Zhang, Jianlei Hao, Libing Zhou, Frederic Bornancin, Zhizhong Li*, Zhinan Yin*, Yunfei Gao*. Inhibition of MALT1 paracaspase activity improves lesion recovery following spinal cord injury.Science Bulletin. 2019, 64(16): 1179-1194.

授权国家发明专利

1.高云飞,黎鹏,尹芝南,王笑,吴阮,维生素D受体及配体在提高免疫细胞抗肿瘤能力中的应用, 2021-6-11,中国, ZL201910861612.2. (发明专利)。

2.高云飞,尹芝南,黎鹏,郑良焰,维生素D3或其活性形式1α,25(OH)₂D₃在抑制PD-1表达中的应用, 2021-7-27,中国, ZL201711248940.2. (发明专利)。