刘佳，深圳理工大学细胞与基因技术研究院特聘副教授，医学博士，具有医学肿瘤学、免疫学和基因组学交叉研究背景，曾在美国Hackensack Meridian Health和Dana-Farber Cancer Institute从事博士后研究。主要从事肿瘤免疫及细胞治疗研究，致力于解析CAR-T细胞及CD8⁺ T细胞记忆形成和耗竭过程中的表观遗传与三维基因组调控机制。近年来发表学术论文11篇，以第一作者或共同第一作者在Journal of Experimental Medicine、PNAS、Nature Communications等杂志发表多篇论文。课题组将围绕CAR-T细胞治疗开展研究，探索克服T细胞耗竭及提高抗肿瘤效应的新机制与新策略。

2007.09—2012.06 青岛大学医学院，临床医学，学士

2012.07—2013.08 北大医疗鲁中医院，住院医师

2013.09—2016.06 山东第一医科大学，肿瘤放射治疗学，硕士（专业学位）

2016.09—2020.06 山东大学齐鲁医学院，肿瘤免疫与生物治疗，博士（学术学位）

2020.12—2023.10 Hackensack Meridian Health，免疫学，博士后

2023.11—2025.08 Dana-Farber Cancer Institute，肿瘤学，博士后

2026.08—至今 深圳理工大学细胞与基因技术研究院，特聘副教授

肿瘤免疫，CAR-T细胞治疗，T细胞耗竭，表观遗传调控，三维基因组

代表性成果

1.Liu J, Zhu S, Hu W, Zhao X, Shan Q, Peng W, Xue HH. CTCF mediates CD8+ effector differentiation through dynamic redistribution and genomic reorganization.Journal of Experimental Medicine. 2023;220(4).

2.Zhu S*,Liu J*, Patel V, Zhao X, Peng W, Xue HH. Antigen exposure reshapes chromatin architecture in central memory CD8+ T cells and imprints enhanced recall capacity.Proceedings of the National Academy of Sciences of the United States of America. 2023;120(51).

3.Liu J, Hao S, Chen X, Zhao H, Du L, Ren H, Wang C, Mao H. Human placental trophoblast cells contribute to maternal-fetal tolerance through expressing IL-35 and mediating iTR35 conversion.Nature Communications. 2019;10:4601.

4.Shan Q, Zhu S, Chen X,Liu J, Yuan S, Li X, Peng W, Xue HH. Tcf1-CTCF cooperativity shapes genomic architecture to promote CD8+ T cell homeostasis.Nature Immunology. 2022;23(8):1222-1235.

5.Liu J, Mao Y, Li Z, Zhang D, Zhang Z, Hao S, Li B. Use of texture analysis based on contrast-enhanced MRI to predict treatment response to chemoradiotherapy in nasopharyngeal carcinoma.Journal of Magnetic Resonance Imaging. 2016;44(2):445-455.

6.Liu J, Dong N, Li N, Zhao H, Li Y, Mao H, Ren H, Feng Y, Liu J, Du L, et al. IL-35 enhances angiogenic effects of small extracellular vesicles in breast cancer.The FEBS Journal. 2022;289(12):3489-3504.

7.Liu J, Chen X, Hao S, Zhao H, Pang L, Wang L, Ren H, Wang C, Mao H. Human chorionic gonadotropin and IL-35 contribute to the maintenance of peripheral immune tolerance during pregnancy through mediating the generation of IL-10+ or IL-35+ Breg cells.Experimental Cell Research. 2019;383(2):111513.

8.Fan L, Cao Q,Liu J, Zhang J, Li B. Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.Molecular Cancer. 2019;18(1):16.

9.Hao S, Chen X, Wang F, Shao Q,Liu J, Zhao H, Yuan C, Ren H, Mao H. Breast cancer cell-derived IL-35 promotes tumor progression via induction of IL-35-producing induced regulatory T cells.Carcinogenesis. 2018;39(12):1488-1496.

10.Mao Y, Fu Z, Zhang Y, Dong L, Zhang Y, Zhang Q, Li X,Liu J. A seven-lncRNA signature predicts overall survival in esophageal squamous cell carcinoma.Scientific Reports. 2018;8(1):8823.

11.Mao Y, Wang J, Wang Y, Fu Z, Dong L,Liu J. Hypoxia induced exosomal Circ-ZNF609 promotes pre-metastatic niche formation and cancer progression via miR-150-5p/VEGFA and HuR/ZO-1 axes in esophageal squamous cell carcinoma.Cell Death Discovery. 2024;10(1):133.