Fang Zhuangjie, Distinguished Associate Professor and Master’s Supervisor at the Institute of Cell and Gene Technology, Shenzhen University of Advanced Technology. He received his Master’s degree in 2019 and Ph.D. degree in 2023 from the South China Sea Institute of Oceanology, Chinese Academy of Sciences. He has been awarded the National Scholarship for Doctoral Students, Beijing Outstanding Graduate, and the Second Prize of the Di’ao Scholarship of the Chinese Academy of Sciences. During his graduate studies and postdoctoral training, he focused on the discovery and biosynthesis of bioactive natural prDistinguished Associate Professor

oducts from marine microorganisms. He has published 12 papers in international peer-reviewed journals, includingNatural Products Reports,Organic Letters, andJournal of Natural Products, among which 5 as first or co-first author. He has also been granted 2 Chinese invention patents. He has served as Principal Investigator of projects supported by the Chinese Academy of Sciences Special Research Assistant Program and the Nansha Postdoctoral Research Funding Program, and participated in projects funded by the National Natural Science Foundation of China (International (Regional) Cooperation and Exchange Program, General Program) and the Guangdong Basic and Applied Basic Research Foundation (General Program).

2012.09–2016.06, B.S. in Biotechnology, Guangdong University of Petrochemical Technology

2016.09–2019.06, M.S. in Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences

2019.09–2023.06, Ph.D. in Marine Biology, South China Sea Institute of Oceanology, Chinese Academy of Sciences

2023.07–2026.04, Postdoctoral Researcher, Environmental Science and Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences

2026.05–present, Distinguished Associate Professor, Institute of Cell and Gene Technology, Shenzhen University of Advanced Technology

Identification of bioactive metabolites in biocontrol fungi and elucidation of their mechanisms of action; development of elite biocontrol strains and their translational applications.

Funded Projects (Principal Investigator / Participant):

(1) Chinese Academy of Sciences, Special Research Assistant Program, Nov 2023–Jan 2026, RMB 800,000, Completed, PI;

(2) Nansha District Talent Development Bureau, Postdoctoral Research Funding Program, Jun 2024–Dec 2024, RMB 150,000, Completed, PI;

(3) National Natural Science Foundation of China, International (Regional) Cooperation and Exchange Program, Jan 1, 2019–Dec 31, 2023, RMB 2,610,000, Completed, Participant;

(4) National Natural Science Foundation of China, General Program, Jan 1, 2021–Dec 31, 2024, RMB 630,000, Completed, Participant;

(5) National Natural Science Foundation of China, General Program, Jan 1, 2019–Dec 31, 2022, RMB 550,000, Completed, Participant;

(6) Guangdong Basic and Applied Basic Research Foundation, General Program, Jan 2021–Dec 2023, RMB 100,000, Completed, Participant.

Representative Publications:

[1]Zhuangjie Fang, Qingbo Zhang,* Weiliang Xiong, Lili Sun, Bin Tan, Mengyi Zhu, Liang Ma, Liping Zhang, Yiguang Zhu, Changsheng Zhang.* Discovery of Tetronate-containing Kongjuemycins from a Coral-associated Actinomycete and Elucidation of Their Biosynthetic Origin.Organic Letters, 2023, 25 (34): 6346-6351.

[2]Zhuangjie Fang, Qingbo Zhang,* Liping Zhang, Jianglian She, Jie Li, Wenjun Zhang, Haibo Zhang, Yiguang Zhu, Changsheng Zhang*. Antifungal Macrolides Kongjuemycins from Coral-associated Rare ActinomycetePseudonocardia kongjuensisSCSIO 11457.Organic Letters, 2022, 24 (19): 3482–3487.

[3]Zhuangjie Fang, Xiaodong Jiang, Qingbo Zhang,* Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, Changsheng Zhang*. S-Bridged thioether and structure-diversified angucyclinone derivatives from the South China Sea-derivedMicromonospora echinosporaSCSIO 04089.Journal of Natural Products, 2020, 83 (10): 3122-3130.

[4]Zhuangjie Fang, Siqiang Chen, Yiguang Zhu, Jie Li, Imran Khan, Qingbo Zhang,* Changsheng Zhang. A new uridine derivative and a new indole derivative from the coral-associated actinomycetePseudonocardiasp. SCSIO 11457.Natural Product Research, 2021, 35 (2): 188-194.

[5] Xiaodong Jiang,^#Zhuangjie Fang,^#Qingbo Zhang,* Wei Liu, Liping Zhang, Wenjun Zhang, Chunfang Yang, Haibo Zhang, Yiguang Zhu, and Changsheng Zhang.* Discovery of a New Asymmetric Dimer Nenestatin B and Implications of Dimerizing Enzyme in a Deep Sea Actinomycete.Organic & Biomolecular Chemistry, 2021, 19 (19): 4243-4247.

[6] Ruijie Chen, Lihan Zhang, Xiaoyang Zhao,Zhuangjie Fang, Liping Zhang, Qingbo Zhang*, Changsheng Zhang,* and Yiguang Zhu.* Discovery, bioactivity and biosynthesis of spirooxindole alkaloids.Natural Product Reports, 2026, DOI: 10.1039/d5np00046g.

[7] Youzhe Chen,^#Hongbo Jin,^#Weiliang Xiong,Zhuangjie Fang, Weiguang Sun,Yiguang Zhu, Liping Zhang, Yonghui Zhang, Wenjun Zhang,* Changsheng Zhang.* Discovery of Aburatubolactams Reveals Biosynthetic Logic for Distinct 5/5-Type Polycyclic Tetramate Macrolactams.Organic Letters, 2024, 26 (8): 1677–1682.

[8] Liping Zhang,^#Bidhan Chandra De,^#Wenjun Zhang,* Attila Mándi,Zhuangjie Fang, Chunfang Yang, Yiguang Zhu, Tibor Kurtán, and Changsheng Zhang.* Mutation of an atypical oxirane oxyanion hole improves regioselectivity of theα/β-fold epoxide hydrolase Alp1U.Journal of Biological Chemistry, 2020, 295 (50): 16987-16997.

Patents:

1. Zhang Changsheng,Fang Zhuangjie, Zhang Qingbo, Zhang Liping, Li Jie, Zhang Wenjun, Zhang Haibo, Zhu Yiguang. Kongjuemycins: A Class of Macrolide Compounds, Their Preparation Methods and Applications. Chinese Invention Patent, ZL202210418878.1, Feb 9, 2024

2. Zhang Changsheng, Zhang Haibo, Imran Khan, Peng Jing,Fang Zhuangjie, Liu Wei, Zhang Wenjun, Zhang Qingbo, Ma Liang, Zhang Guangtao. Cylindromicin: A Compound and Its Preparation Methods and Applications. Chinese Invention Patent, ZL202110003044.X, Jul 12, 2022